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Acute colitis

MedGen UID:
451087
•Concept ID:
C2118460
•
Disease or Syndrome
HPO: HP:0100282

Definition

An acute and self-limited inflammatory disease of the large intestine (colon, cecum and rectum). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute colitis

Professional guidelines

PubMed

Approach to the patient with infectious colitis: clinical features, work-up and treatment.
Iqbal T, DuPont HL
Curr Opin Gastroenterol 2021 Jan;37(1):66-75. doi: 10.1097/MOG.0000000000000693. PMID: 33105253
The Differential Diagnosis of Acute Colitis: Clues to a Specific Diagnosis.
Jessurun J
Surg Pathol Clin 2017 Dec;10(4):863-885. doi: 10.1016/j.path.2017.07.008. PMID: 29103537
Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer.
Zhang M, Viennois E, Prasad M, Zhang Y, Wang L, Zhang Z, Han MK, Xiao B, Xu C, Srinivasan S, Merlin D
Biomaterials 2016 Sep;101:321-40. Epub 2016 Jun 9 doi: 10.1016/j.biomaterials.2016.06.018. PMID: 27318094Free PMC Article

Recent clinical studies

Etiology

Nucleophosmin 1 promotes mucosal immunity by supporting mitochondrial oxidative phosphorylation and ILC3 activity.
Zhao R, Yang J, Zhai Y, Zhang H, Zhou Y, Hong L, Yuan D, Xia R, Liu Y, Pan J, Shafi S, Shi G, Zhang R, Luo D, Yuan J, Pan D, Peng C, Li S, Sun M
Nat Immunol 2024 Sep;25(9):1565-1579. Epub 2024 Aug 5 doi: 10.1038/s41590-024-01921-x. PMID: 39103576Free PMC Article
Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway.
Xu C, Ye Z, Jiang W, Wang S, Zhang H
Mol Med 2023 Dec 13;29(1):169. doi: 10.1186/s10020-023-00758-8. PMID: 38093197Free PMC Article
Faecalibacterium prausnitzii, Bacteroides faecis and Roseburia intestinalis attenuate clinical symptoms of experimental colitis by regulating Treg/Th17 cell balance and intestinal barrier integrity.
Mohebali N, Weigel M, Hain T, Sütel M, Bull J, Kreikemeyer B, Breitrück A
Biomed Pharmacother 2023 Nov;167:115568. Epub 2023 Oct 2 doi: 10.1016/j.biopha.2023.115568. PMID: 37793274
Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development.
Zhou L, Liu T, Huang B, Luo M, Chen Z, Zhao Z, Wang J, Leung D, Yang X, Chan KW, Liu Y, Xiong L, Chen P, Wang H, Ye L, Liang H, Masters SL, Lew AM, Gong S, Bai F, Yang J, Pui-Wah Lee P, Yang W, Zhang Y, Lau YL, Geng L, Zhang Y, Cui J
J Allergy Clin Immunol 2021 Jan;147(1):267-279. Epub 2020 Sep 15 doi: 10.1016/j.jaci.2020.09.003. PMID: 32941940
Glutaraldehyde-induced colitis.
Stein BL, Lamoureux E, Miller M, Vasilevsky CA, Julien L, Gordon PH
Can J Surg 2001 Apr;44(2):113-6. PMID: 11308232Free PMC Article

Diagnosis

Enteric glia promote visceral hypersensitivity during inflammation through intercellular signaling with gut nociceptors.
Morales-Soto W, Gonzales J, Jackson WF, Gulbransen BD
Sci Signal 2023 Nov 21;16(812):eadg1668. doi: 10.1126/scisignal.adg1668. PMID: 37988454Free PMC Article
Approach to the patient with infectious colitis: clinical features, work-up and treatment.
Iqbal T, DuPont HL
Curr Opin Gastroenterol 2021 Jan;37(1):66-75. doi: 10.1097/MOG.0000000000000693. PMID: 33105253
The Differential Diagnosis of Acute Colitis: Clues to a Specific Diagnosis.
Jessurun J
Surg Pathol Clin 2017 Dec;10(4):863-885. doi: 10.1016/j.path.2017.07.008. PMID: 29103537
Flucytosine-induced colitis.
Sohail MA, Ikram U
BMJ Case Rep 2014 Apr 28;2014 doi: 10.1136/bcr-2013-203381. PMID: 24777084Free PMC Article
Fulminant colitis.
Portela F, Lago P
Best Pract Res Clin Gastroenterol 2013 Oct;27(5):771-82. Epub 2013 Sep 6 doi: 10.1016/j.bpg.2013.08.011. PMID: 24160933

Therapy

Novel bispecific nanobody mitigates experimental intestinal inflammation in mice by targeting TNF-α and IL-23p19 bioactivities.
Wang J, Kang G, Lu H, de Marco A, Yuan H, Feng Z, Gao M, Wang X, Wang H, Zhang X, Wang Y, Zhang M, Wang P, Feng Y, Liu Z, Cao X, Huang H
Clin Transl Med 2024 Mar;14(3):e1636. doi: 10.1002/ctm2.1636. PMID: 38533646Free PMC Article
DSS-induced inflammation in the colon drives a proinflammatory signature in the brain that is ameliorated by prophylactic treatment with the S100A9 inhibitor paquinimod.
Talley S, Valiauga R, Anderson L, Cannon AR, Choudhry MA, Campbell EM
J Neuroinflammation 2021 Nov 10;18(1):263. doi: 10.1186/s12974-021-02317-6. PMID: 34758843Free PMC Article
Approach to the patient with infectious colitis: clinical features, work-up and treatment.
Iqbal T, DuPont HL
Curr Opin Gastroenterol 2021 Jan;37(1):66-75. doi: 10.1097/MOG.0000000000000693. PMID: 33105253
Hyaluronic acid-bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis.
Lee Y, Sugihara K, Gillilland MG 3rd, Jon S, Kamada N, Moon JJ
Nat Mater 2020 Jan;19(1):118-126. Epub 2019 Aug 19 doi: 10.1038/s41563-019-0462-9. PMID: 31427744Free PMC Article
Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer.
Zhang M, Viennois E, Prasad M, Zhang Y, Wang L, Zhang Z, Han MK, Xiao B, Xu C, Srinivasan S, Merlin D
Biomaterials 2016 Sep;101:321-40. Epub 2016 Jun 9 doi: 10.1016/j.biomaterials.2016.06.018. PMID: 27318094Free PMC Article

Prognosis

Ultrasound diagnosis of typhlitis.
Tamburrini S, Setola FR, Belfiore MP, Saturnino PP, Della Casa MG, Sarti G, Abete R, Marano I
J Ultrasound 2019 Mar;22(1):103-106. Epub 2018 Oct 27 doi: 10.1007/s40477-018-0333-2. PMID: 30367357Free PMC Article
Checkpoint inhibitor colitis: a new model of inflammatory bowel disease?
Siakavellas SI, Bamias G
Curr Opin Gastroenterol 2018 Nov;34(6):377-383. doi: 10.1097/MOG.0000000000000482. PMID: 30157044
Fulminant colitis.
Portela F, Lago P
Best Pract Res Clin Gastroenterol 2013 Oct;27(5):771-82. Epub 2013 Sep 6 doi: 10.1016/j.bpg.2013.08.011. PMID: 24160933
Hepatic amebiasis.
Salles JM, Moraes LA, Salles MC
Braz J Infect Dis 2003 Apr;7(2):96-110. Epub 2003 Nov 19 doi: 10.1590/s1413-86702003000200002. PMID: 12959680
Glutaraldehyde-induced colitis.
Stein BL, Lamoureux E, Miller M, Vasilevsky CA, Julien L, Gordon PH
Can J Surg 2001 Apr;44(2):113-6. PMID: 11308232Free PMC Article

Clinical prediction guides

Dihydromyricetin ameliorates experimental ulcerative colitis by inhibiting neutrophil extracellular traps formation via the HIF-1α/VEGFA signaling pathway.
Ma X, Li M, Wang X, Xu H, Jiang L, Wu F, Wei L, Qi G, Zhang D
Int Immunopharmacol 2024 Sep 10;138:112572. Epub 2024 Jul 1 doi: 10.1016/j.intimp.2024.112572. PMID: 38955027
Inhibition of FABP5 attenuates inflammatory bowel disease by modulating macrophage alternative activation.
Xu J, Zheng B, Xie C, Zhao Y, Wu H, Wang Y, Guan X, Lei X, Liu D, Lou X, Chen X, Huang Y
Biochem Pharmacol 2024 Jan;219:115974. Epub 2023 Dec 10 doi: 10.1016/j.bcp.2023.115974. PMID: 38081366
Faecalibacterium prausnitzii, Bacteroides faecis and Roseburia intestinalis attenuate clinical symptoms of experimental colitis by regulating Treg/Th17 cell balance and intestinal barrier integrity.
Mohebali N, Weigel M, Hain T, Sütel M, Bull J, Kreikemeyer B, Breitrück A
Biomed Pharmacother 2023 Nov;167:115568. Epub 2023 Oct 2 doi: 10.1016/j.biopha.2023.115568. PMID: 37793274
Reduced smooth muscle-fibroblasts transformation potentially decreases intestinal wound healing and colitis-associated cancer in ageing mice.
Liu Y, Ji Y, Jiang R, Fang C, Shi G, Cheng L, Zuo Y, Ye Y, Su X, Li J, Wang H, Wang Y, Lin Y, Dai L, Zhang S, Deng H
Signal Transduct Target Ther 2023 Aug 9;8(1):294. doi: 10.1038/s41392-023-01554-w. PMID: 37553378Free PMC Article
Host-microbiota interaction-mediated resistance to inflammatory bowel disease in pigs.
Zhao X, Jiang L, Fang X, Guo Z, Wang X, Shi B, Meng Q
Microbiome 2022 Jul 30;10(1):115. doi: 10.1186/s40168-022-01303-1. PMID: 35907917Free PMC Article

Recent systematic reviews

Systematic review and meta-analysis of laparoscopic versus open colectomy with end ileostomy for non-toxic colitis.
Bartels SA, Gardenbroek TJ, Ubbink DT, Buskens CJ, Tanis PJ, Bemelman WA
Br J Surg 2013 May;100(6):726-33. Epub 2013 Jan 25 doi: 10.1002/bjs.9061. PMID: 23355043
Colectomy in patients with acute colitis: a systematic review.
Teeuwen PH, Stommel MW, Bremers AJ, van der Wilt GJ, de Jong DJ, Bleichrodt RP
J Gastrointest Surg 2009 Apr;13(4):676-86. Epub 2009 Jan 9 doi: 10.1007/s11605-008-0792-4. PMID: 19132451

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